| Quarterback | Wk 1 | Wk 2 | total |
|---|---|---|---|
| Brock Purdy |
71 99% |
70 100% |
141 |
| Brandon Allen |
1 1% |
0 | 1 | Running Back | Wk 1 | Wk 2 | total |
| Jordan Mason |
58 81% |
57 81% |
115 |
| Kyle Juszczyk |
40 56% |
40 57% |
80 |
| Isaac Guerendo |
3 4% |
1 1% |
4 |
| Patrick Taylor Jr. |
0 0% |
0 0% |
0 | Wide Receiver | Wk 1 | Wk 2 | total |
| Deebo Samuel Sr. |
53 74% |
60 86% |
113 |
| Brandon Aiyuk |
43 60% |
61 87% |
104 |
| Jauan Jennings |
35 49% |
38 54% |
73 |
| Chris Conley |
29 40% |
9 13% |
38 |
| Ronnie Bell |
13 18% |
6 9% |
19 |
| Jacob Cowing |
0 0% |
0 0% |
0 | Tight End | Wk 1 | Wk 2 | total |
| George Kittle |
66 92% |
51 73% |
117 |
| Eric Saubert |
19 26% |
26 37% |
45 |
| Jake Tonges |
1 1% |
1 1% |
2 | Defensive Tackle | Wk 1 | Wk 2 | total |
| Maliek Collins |
37 73% |
36 67% |
73 |
| Javon Hargrave |
32 63% |
33 61% |
65 |
| Kevin Givens |
18 35% |
19 35% |
37 |
| Jordan Elliott |
15 29% |
20 37% |
35 |
| Sam Okuayinonu |
14 27% |
0 | 14 | Defensive End | Wk 1 | Wk 2 | total |
| Nick Bosa |
48 94% |
46 85% |
94 |
| Leonard Floyd |
34 67% |
32 59% |
66 |
| Yetur Gross-Matos | 0 |
26 48% |
26 | Linebacker | Wk 1 | Wk 2 | total |
| Fred Warner |
51 100% |
54 100% |
105 |
| De'Vondre Campbell |
51 100% |
51 94% |
102 |
| Demetrius Flannigan-Fowles |
12 24% |
20 37% |
32 |
| Robert Beal Jr. |
6 12% |
4 7% |
10 |
| Tatum Bethune |
0 0% |
0 0% |
0 |
| Curtis Robinson |
0 0% |
0 0% |
0 | Cornerback | Wk 1 | Wk 2 | total |
| Deommodore Lenoir |
51 100% |
54 100% |
105 |
| Charvarius Ward |
51 100% |
53 98% |
104 |
| Isaac Yiadom |
39 76% |
34 63% |
73 |
| Renardo Green |
0 0% |
4 7% |
4 |
| Rock Ya-Sin |
0 0% |
0 0% |
0 | Safety | Wk 1 | Wk 2 | total |
| Ji'Ayir Brown |
51 100% |
54 100% |
105 |
| George Odum |
51 100% |
23 43% |
74 |
| Malik Mustapha |
0 0% |
31 57% |
31 |
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