Week 16 matchup previews compiled by Dave Kluge with all the news and notes pertinent to Week 16 of NFL fantasy football.
Week 16 Bye Weeks
None
Week 16 Thursday Night Football
Denver Broncos @ Los Angeles Chargers
Saturday Early Game - Saturday, 1:00 pm ET
Houston Texans @ Kansas City Chiefs
- Joe Mixon (ankle) limited, removed from Thursday’s injury report, will play in Week 16
- John Metchie III (shoulder) did not practice
- Patrick Mahomes II (ankle) practicing in full, expected to play in Week 16
- Marquise Brown (shoulder) practicing in full, expected to make season debut in Week 16
Saturday Afternoon Game - Saturday, 4:30 pm ET
Pittsburgh Steelers @ Baltimore Ravens
- George Pickens (hamstring) did not practice, not expected to play in Week 16
- Justin Fields (abdominal) did not practice
- Nelson Agholor (concussion) did not practice
- Rashod Bateman (foot) limited Wednesday, did not practice Thursday
- Diontae Johnson (personal) did not practice, taking “excused leave” in Week 16
- Justice Hill (personal) did not practice Wednesday
Sunday Early Games - Sunday, 1:00 pm ET
New York Giants @ Atlanta Falcons
- Malik Nabers (knee/foot) limited Wednesday
- Wan'Dale Robinson (shoulder) limited Wednesday
- Tyrone Tracy Jr.. (ankle) limited
- Tommy DeVito (concussion) limited
- Drew Lock (heel/left elbow) limited Wednesday
- Drew Lock expected to start in Week 16
- Darnell Mooney (rest) limited
- KhaDarel Hodge (ribs) limited Wednesday, did not practice Thursday
- Ross Dwelley (ankle) limited
- Charlie Woerner (quad) limited
- Michael Penix Jr. expected to start in Week 16 and going forward
Arizona Cardinals @ Carolina Panthers
- Trey Benson (ankle) did not practice
- Xavier Legette (hip) did not practice
- Chuba Hubbard (rest) did not practice Wednesday
- Adam Thielen (rest) did not practice Wednesday
- Jalen Coker (quadriceps) limited Thursday
- David Moore (concussion) limited
Detroit Lions @ Chicago Bears
- David Montgomery (knee) did not practice, hopes to return from MCL injury for playoffs
- Amon-Ra St. Brown (rest) did not practice Wednesday
- HC Dan Campbell is confident Jahmyr Gibbs can handle a workhorse role
- Roschon Johnson (concussion) practicing in full
Tennessee Titans @ Indianapolis Colts
- Tony Pollard (ankle) did not practice
- Tyler Boyd (foot) did not practice
- Nick Westbrook-Ikhine (ankle) did not practice
- Mason Rudolph expected to start in Week 16
- Michael Pittman Jr (back) did not practice Wednesday
- Alec Pierce (concussion) did not practice
Los Angeles Rams @ New York Jets
- Jordan Whittington (shoulder) practicing in full
- Demarcus Robinson (shoulder) practicing in full
- Tyler Higbee (knee) did not practice Thursday, activated off PUP list, expected to make season debut in Week 16
- Braelon Allen (back) limited
- Isaiah Davis (back) limited
- Jets signed Zach Evans to practice squad
Philadelphia Eagles @ Washington Commanders
- Saquon Barkley (rest) did not practice Wednesday
- A.J. Brown (knee/rest) did not practice Wednesday, limited Thursday
- Jalen Hurts (left finger) practicing in full
- DeVonta Smith (back/rest) did not practice Wednesday
- Zach Ertz (concussion) did not practice Wednesday, limited Thursday
- Luke McCaffrey (shoulder) limited
Cleveland Browns @ Cincinnati Bengals
- Jerry Jeudy (knee) practicing in full
- Cedric Tillman (concussion) limited, hopeful to play in Week 16
- David Njoku (knee) did not practice
- Nick Chubb (foot) placed on IR, will not play this season
- Jameis Winston (right shoulder) limited Thursday
- Dorian Thompson-Robinson expected to start in Week 16
- Joe Burrow (right wrist/knee) limited
- Tee Higgins (rest/knee) limited Wednesday, did not practice Thursday
Sunday Afternoon Games - Sunday, 4:05-4:25 pm ET
Minnesota Vikings @ Seattle Seahawks
- Zach Charbonnet (oblique) did not practice Wednesday, limited Thursday
- Ken Walker III (calf) did not practice Wednesday
- DK Metcalf (shoulder) did not practice Wednesday
- Tyler Lockett (rest) did not practice Wednesday
- Noah Fant (knee) limited Wednesday
- Geno Smith (knee) practicing in full
New England Patriots @ Buffalo Bills
- Javon Baker (concussion) limited Wednesday
- Amari Cooper (wrist) practicing in full
- Curtis Samuel (rib) limited
- Dalton Kincaid (knee) practicing in full
Jacksonville Jaguars @ Las Vegas Raiders
- Brenton Strange (shoulder) limited
- Evan Engram (shoulder) underwent surgery, will not play this season
- Trevor Lawrence (concussion/shoulder) underwent surgery, will not play this season
- Alexander Mattison (neck) practicing full
- Jakobi Meyers (ankle) limited
- Aidan O'Connell (knee) practicing in full, expected to return in Week 16
- Desmond Ridder (hip) practicing in full
- Sincere McCormick (ankle) placed on IR, will not play this season
San Francisco 49ers @ Miami Dolphins
- Isaac Guerendo (foot/hamstring) did not practice, unlikely to play in Week 16
- Tyreek Hill (wrist/rest) did not practice Wednesday
- Jaylen Waddle (knee) did not practice, avoids major injury
- De'Von Achane (groin) practicing in full
- Tua Tagovailoa (hip) limited
Week 16 Sunday Night Football - Sunday, 8:20 pm ET
Tampa Bay Buccaneers @ Dallas Cowboys
- Mike Evans (rest) did not practice Wednesday, limited Thursday
- Sterling Shepard (foot) did not practice Wednesday, limited Thursday
- Trey Palmer (illness) did not practice Thursday
- Bucky Irving (back/hip) limited
- Baker Mayfield (knee) limited Wednesday
- Cade Otton (knee) did not practice
- CeeDee Lamb (shoulder) limited Wednesday
- Rico Dowdle (knee) practicing in full
Week 16 Monday Night Football - Monday, 8:00-8:30 pm ET
New Orleans Saints @ Green Bay Packers
- Derek Carr (left hand) did not practice
- Alvin Kamara (groin) did not practice, could miss rest of season
- Marquez Valdes-Scantling (chest) did not practice
- Chris Olave (head) limited
- Juwan Johnson (foot) limited
- Spencer Rattler expected to start in Week 16
- Saints signed Clyde Edwards-Helaire to practice squad
- Luke Musgrave (ankle) limited
Photos provided by Imagn Images