Key: 

Position Player, Team | Injury | Projected Return to Play

RB Christian McCaffrey,  San Francisco | Knee | Likely Season-Ending

The Christian McCaffrey roller coaster may have finally come to an end. The ride was not fun, and the ending may be even less enjoyable. McCaffrey started Sunday night's game well, but his night was short-lived. While taking a handoff, McCaffrey game himself up and appeared to be dealing with an apparent right leg injury.

yikes --- Christian McCaffrey pic.twitter.com/RiwvgHWpjU

— ??O ?OOT???? ?O????? ? (@NFL_Journal) December 2, 2024

Video showed that McCaffrey likely injured himself a few plays prior. His mechanism of injury fit that of a PCL sprain - very similar to the one Dalton Kincaid suffered earlier in Week 10.

The previous #CMC play is likely where knee injury happens. Worry for right knee PCL sprain on shoestring tackle. The next run, he doesn't feel right and goes down. pic.twitter.com/aeQfmoS53x

— David J. Chao - ProFootballDoc (@ProFootballDoc) December 2, 2024

PCL sprains vary in severity and thus the return to play timeline can also have a wide range. Minor sprains result in 0-2 weeks missed. More serious sprains can be 6+ weeks. Full tears require season-ending surgery. It sounds like McCaffrey's knee injury is serious.

After the game, ESPN's Adam Schefter reported that McCaffrey's season might very well be over.

Kyle Shanahan said Christian McCaffrey suffered a potentially season-ending PCL injury.

— Adam Schefter (@AdamSchefter) December 2, 2024

The 49ers will hopefully provide some clarification but even without a full tear, a serious sprain would end McCaffrey's season considering there are only 5 more games left in the regular season. 

TE/QB, Taysom Hill, New Orleans | Knee | Likely Season-Ending 

Taysom Hill's season is likely over after a knee injury during Sunday's loss to the Los Angeles Rams. By video, it appeared that Hill suffered an ACL tear and potentially more. Sunday night, NFL Network's Ian Rapoport confirmed by suspicion.

#Saints do-it-all TE Taysom Hill, who was carted off today, is feared to have suffered a season-ending knee injury, sources say.

No final diagnosis yet, as he’ll have an MRI to determine the severity of the injury. But feared to be significant. A tough blow. pic.twitter.com/4vNFFVE6dw

— Ian Rapoport (@RapSheet) December 2, 2024

The Saints will wait for more test results before making an official statement but it would appear that Hill's 2024 season is over.