San Francisco 49ers RB Isaac Guerendo (foot, hamstring) and OT Trent Williams (ankle) did not practice on Friday, Dec. 20, and were ruled out for Week 16. Also, DL Robert Beal Jr. (ankle), DE Nick Bosa (hip, oblique) and LB Dre Greenlaw (Achilles, knee) were limited and are questionable and OG Aaron Banks (elbow), S Ji'Ayir Brown (groin), DT Maliek Collins (illness), LB Demetrius Flannigan-Fowles (knee), S Talanoa Hufanga (wrist), OT Jaylon Moore (hip), S Malik Mustapha (chest), LB Dee Winters (neck) and OG Nick Zakelj (illness) practiced in full and were removed from the injury report.